It turns out that the drawing of the molecule made by Geo Kreese was seen as promoting banned substances. So I'm reposting with a...

In 2002, I popularized synthetic cathinone, which was also the first psychoactive compound I developed (followed by many more). The idea...

A subspace of the Analogue Space of Cathinone I find that one of the most confusing and therefore problematic things about the perception...

From personal experience, all of the materials I have developed do not produce physiological dependence,

It turns out that tobacco contains a relatively unknown MAOI called Harman

In 1860, a German scientist named Albert Niemann extracted and isolated the active ingredient in coca leaves for the first time and gave...

The first is an experience that Alexander Shulgin documented and devoted an entire chapter to in PiHKaL, the second is actually an experience from my own personal life. Chapter 13 in PiHKaL is called "Time Stop"

The nitrogen atom can be likened to the metal ring that serves as an opener in a can of Coca-Cola. When we want to open the can, our finger knows how to recognize the ring and pull on it, just like the enzyme responsible for activating the receptor knows how to recognize the single nitrogen atom and take the electron from it.

This testimony of Xenophon, from more than 2,500 years ago, is the earliest documentation of a unique phenomenon known as 'mad honey'.

But what if you are the kind of organism that can't move (like plants or fungi)? For example - let's suppose that you're an acacia tree on the African Savannah and you don't have access to very much water and therefore, the fleshy part of your leaves are very precious to you, and you would rather not have harvester ants cut them up and take them away

Smoking 5-MeO-DMT gives the person who inhales it a strong yet short lasting meeting with God. The bufo toads are probably the most prominent example of Zoopsychedelics, but are they alone?

“The urine seems to be more powerful than the mushroom and its effect May last through the 4th or 5th man.”

Amanita muscaria does not have psilocybin AT ALL. It is really something else, on the other hand, there is also the ibotenic acid, which is a turn-off.

So, in a calculated move, I decided for the first time in my life to change my consciousness proactively and simply get drunk, and that's what happened. The experiment was pleasant and successful.

The good people of NIDA made generous development budgets available to researchers who would develop synthetic versions of natural cannabinoids such as THC or CBD. The most diligent and prolific researcher who used NIDA money to this end was an American professor of organic chemistry named John William Huffman, who developed over 400 such analogs.

mind-altering can sometimes produce value and benefit in surprising ways that are very difficult to predict.

Cathinone is very similar to a neurotransmitter that exists in invertebrates (which includes insects) called octopamine

Shulgin performed hundreds of experiments on himself and got to live a long and healthy life. Shulgin published his experiences, research and recipes in two books that he wrote together with his wife and partner Ann - PiHKAL (179 substances) and TiHKAL (55 substances).

The effect of drugs on those who don't take them...

Why are we attracted to drugs at all?

Some of you may have heard of the 2023 film "King Khat". The movie's protagonist is a guy called Gabi (a classical SWIM). One of the...