In 2002, I popularized synthetic cathinone, which was also the first psychoactive compound I developed (followed by many more). The idea...

From personal experience, all of the materials I have developed do not produce physiological dependence,

It turns out that tobacco contains a relatively unknown MAOI called Harman

In 1860, a German scientist named Albert Niemann extracted and isolated the active ingredient in coca leaves for the first time and gave...

The first is an experience that Alexander Shulgin documented and devoted an entire chapter to in PiHKaL, the second is actually an experience from my own personal life. Chapter 13 in PiHKaL is called "Time Stop"

The nitrogen atom can be likened to the metal ring that serves as an opener in a can of Coca-Cola. When we want to open the can, our finger knows how to recognize the ring and pull on it, just like the enzyme responsible for activating the receptor knows how to recognize the single nitrogen atom and take the electron from it.

So, in a calculated move, I decided for the first time in my life to change my consciousness proactively and simply get drunk, and that's what happened. The experiment was pleasant and successful.

The good people of NIDA made generous development budgets available to researchers who would develop synthetic versions of natural cannabinoids such as THC or CBD. The most diligent and prolific researcher who used NIDA money to this end was an American professor of organic chemistry named John William Huffman, who developed over 400 such analogs.

mind-altering can sometimes produce value and benefit in surprising ways that are very difficult to predict.