In 2002, I popularized synthetic cathinone, which was also the first psychoactive compound I developed (followed by many more). The idea...

The nitrogen atom can be likened to the metal ring that serves as an opener in a can of Coca-Cola. When we want to open the can, our finger knows how to recognize the ring and pull on it, just like the enzyme responsible for activating the receptor knows how to recognize the single nitrogen atom and take the electron from it.

This testimony of Xenophon, from more than 2,500 years ago, is the earliest documentation of a unique phenomenon known as 'mad honey'.

mind-altering can sometimes produce value and benefit in surprising ways that are very difficult to predict.

Shulgin performed hundreds of experiments on himself and got to live a long and healthy life. Shulgin published his experiences, research and recipes in two books that he wrote together with his wife and partner Ann - PiHKAL (179 substances) and TiHKAL (55 substances).